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Description for Protein POLE4

polymerase (DNA-directed), epsilon 4 (p12 subunit)
4 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.7.7
KEGG - Orthology:
K03506
KEGG - Pathway(s):
hsa00230; hsa00240; hsa01100; hsa03030; hsa03410; hsa03420
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Polymerase (DNA-directed), epsilon 4 (p12 subunit); DNA polymerase epsilon subunit 4; p12
Approved Symbol:
POLE4
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cladribine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16238 Entrez Gene ID: 56655 OMIM ID: 607269 Swissprot Accession: Q9NR33;