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Description for Protein DIABLO

diablo homolog (Drosophila)
16 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 8)
Summary:
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10522
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SMAC; Direct IAP binding protein with low pI; SMAC3; DIABLO S; Mitochondrial Smac protein; Second mitochondria derived activator of caspase; Diablo isoform 2; Diablo homolog, mitochondrial; FLJ25049; Diablo isoform 1 precursor; FLJ10537; Diablo isoform 3 precursor
    Approved Symbol:
    DIABLO
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05560 Entrez Gene ID: 56616 OMIM ID: 605219 Swissprot Accession: Q9NR28; Q6W3F3;