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Description for Protein TMPRSS15

transmembrane protease, serine 15
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LDLA: Low-density lipoprotein receptor domain class A
  • TM: Transmembrane domain
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • MAM: Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
  • SEA: Domain found in sea urchin sperm protein, enterokinase, agrin
  • SR: Scavenger receptor Cys-rich
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.9
    KEGG - Orthology:
    K01316
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Enterokinase; ENTK; Proenterokinase
    Approved Symbol:
    TMPRSS15
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Enterokinase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 05972 Entrez Gene ID: 5651 OMIM ID: 606635 Swissprot Accession: P98073;