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Description for Protein MASP1

mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFCA: Calcium-binding EGF-like domain
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
  • SUSHI: Sushi domain (SCR repeat)
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.-
    KEGG - Orthology:
    K03992
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FLJ26383 Protein; MGC126283; MGC126284; Ra-reactive factor serine protease p100; Mannose-binding protein-associated serine protease; Complement activating component of Ra reactive factor; CRARF; MASP; RaRF; PRSS5; CRARF1; Mannan-binding lectin serine protease 1 isoform 2; Mannan-binding lectin serine protease 1 isoform 1; Mannan-binding lectin serine protease 1 isoform 3
    Approved Symbol:
    MASP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02749 Entrez Gene ID: 5648 OMIM ID: 600521 Swissprot Accession: P48740;