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Description for Protein PRSS3

protease, serine, 3
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.4
    KEGG - Orthology:
    K01312
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Trypsin 3; Mesotrypsinogen; Trypsin 4, brain; Brain trypsinogen; Protease, serine, 4; Pancreatic trypsinogen III; TRY3; TRY4; PRSS4
    Approved Symbol:
    PRSS3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,3,2-Dioxaborolan-2-Ol(db);
  • 4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium(db);
  • 4-(Hydroxymethyl)Benzamidine(db);
  • 4-Hydroxybutan-1-Aminium(db);
  • Acetate Ion(db);
  • Benzamidine(db);
  • Fucose(db);
  • Guanidine-3-Propanol(db);
  • [3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine(db);
  • [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06685 Entrez Gene ID: 5646 OMIM ID: - Swissprot Accession: Q6ISJ4; P35030; A8CED1;