Summary:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
SP: Signal Peptide
TRYPSIN: Trypsin-like serine protease
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Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K01312
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KEGG - Pathway(s):
hsa04080
(The yellow boxes represents platelet proteins) |
Nomenclature / Alternative Names:
Serine protease 1; Trypsinogen 1; Cationic trypsinogen; TRY1; TRP1; TRYP1; EC 3.4.21.4
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-Pyrrolidinecarboxamide(db);
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide(db);
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide(db);
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide(db);
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide(db);
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide(db);
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide(db);
+/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE(db);
1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea(db);
1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea(db);
1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid(db);
1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID(db);
2,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitol(db);
2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL(db);
2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine(db);
2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine(db);
2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine(db);
2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine(db);
2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE(db);
2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE(db);
2-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-Carboxamidine(db);
2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE(db);
2-Methyl-2,4-Pentanediol(db);
2-NAPHTHALENESULFONIC ACID(db);
2-O-(3'-AMIDINOPHENYL)-5-O-(4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL(db);
2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL(db);
2-Phenylethylamine(db);
3,5-Diiodotyrosine(db);
3-Phenylpropylamine(db);
3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE(db);
4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE(db);
4-Fluorobenzylamine(db);
4-Iodobenzo[B]Thiophene-2-Carboxamidine(db);
4-Phenylbutylamine(db);
4-PIPERIDIN-4-YLBUTANAL(db);
4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine(db);
5-Amidino-Benzimidazole(db);
5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid(db);
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine(db);
Aeruginosin 98-B(db);
Aminomethylcyclohexane(db);
Amylamine(db);
Aprotinin(db);
Benzamidine(db);
Benzo[B]Thiophene-2-Carboxamidine(db);
Benzylamine(db);
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone(db);
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate(db);
Bis(5-Amidino-2-Benzimidazolyl)Methanone(db);
Bis(5-Amidino-Benzimidazolyl)Methane(db);
Bis(5-Amidino-Benzimidazolyl)Methane Zinc(db);
Bis(5-Amidino-Benzimidazolyl)Methanone Zinc(db);
Bis-Benzamidine(db);
CRA_10433(db);
CRA_10655(db);
CRA_10656(db);
CRA_10762(db);
CRA_10950(db);
CRA_10972(db);
CRA_10991(db);
CRA_11092(db);
CRA_1144(db);
CRA_16847(db);
CRA_17312(db);
CRA_17693(db);
CRA_1801(db);
CRA_1802(db);
CRA_23653(db);
CRA_7806(db);
CRA_8696(db);
CRA_9076(db);
CRA_9334(db);
CRA_9678(db);
CRA_9785(db);
Crc200 (Chiron-Behring)(db);
Cyclohexane(db);
Cyclotheonamide A(db);
diethyl [(1R)-1,5-diaminopentyl]boronate(db);
Dimethyl sulfoxide(db);
Diminazene(db);
Hemi-Babim(db);
Hexane(db);
Isopropyl Alcohol(db);
Monoisopropylphosphorylserine(db);
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine(db);
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester(db);
N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid(db);
N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide(db);
N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide(db);
Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester(db);
O-Benzylsulfonyl-Serine(db);
Phosphorylisopropane(db);
RPR128515(db);
RPR131247(db);
RWJ-51084(db);
Thieno[2,3-B]Pyridine-2-Carboxamidine(db);
Trans-2-Phenylcyclopropylamine(db);
ZK-800270(db);
ZK-805623(db);
Zk-806450(db);
ZK-806711(db);
[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester(db);
[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone(db);
[4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium(db);
[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE(db)
Associated Genetic Diseases:
Pancreatitis, hereditary(Pd)
| Predicted Transmembrane Domains:
| Additional Identifiers:
| HPRD: | 02039 | | Entrez Gene ID: | 5644 | | OMIM ID: | 276000 | | Swissprot Accession: | P07477; | | |
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