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Description for Protein PARD3

par-3 partitioning defective 3 homolog (C. elegans)
35 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 9; undefined: 1)
Summary:
PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04237
    KEGG - Pathway(s):
    hsa04062; hsa04080; hsa04144; hsa04520; hsa04530
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ASIP; CTCL tumor antigen se2 5; PAR3; SE2 5T2; SE2 5L16; SE2 5LT1; PAR3alpha; Partitioning defective 3
    Approved Symbol:
    PARD3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 45
    Human (de-) phosphorylation sites: 45; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05994 Entrez Gene ID: 56288 OMIM ID: 606745 Swissprot Accession: Q8TCZ9; Q8TEW0;