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Description for Protein PROS1

protein S (alpha)
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(alpha granules: 2; membrane: 1; microparticles: 1; platelet: 2; secretome: 2; undefined: 1)
Summary:
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFCA: Calcium-binding EGF-like domain
  • LAMG: Laminin G domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03908
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Vitamin K dependent protein S; PSA; PROSP; Protein S, beta; PROS2; PSB
    Approved Symbol:
    PROS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Antihemophilic Factor(db);
  • Drotrecogin alfa(db);
  • Menadione(db);
  • Sodium Tetradecyl Sulfate(db)

    Associated Genetic Diseases:

  • Protein S deficiency(Pd);
  • Protein S deficiency, type I(Pd);
  • Protein S Heerlen(Pd);
  • Protein S Tokushima(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01473 Entrez Gene ID: 5627 OMIM ID: 176880 Swissprot Accession: P07225;