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Description for Protein PROC

protein C (inactivator of coagulation factors Va and VIIIa)
12 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGF: Epidermal growth factor-like domain.
  • TRYPSIN: Trypsin-like serine protease
  • GLA: Domain containing Gla (gamma-carboxyglutamate) residues.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.69
    KEGG - Orthology:
    K01344
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PC; Blood coagulation factor XIV; Anticoagulant protein C; Autoprothrombin IIA; Vitamin K dependent protein C
    Approved Symbol:
    PROC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Antihemophilic Factor(db);
  • Menadione(db);
  • Sodium Tetradecyl Sulfate(db)

    Associated Genetic Diseases:

  • Protein C deficiency(Pd);
  • Protein C deficiency, autosomal recessive(Pd);
  • Protein C deficiency, type I(Pd);
  • Protein C Nagoya(Pd);
  • Protein C Tochigi(Pd);
  • Protein C Vermont 1(Pd);
  • Protein C Vermont 2(Pd);
  • Thrombophilia due to Protein C deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01466 Entrez Gene ID: 5624 OMIM ID: 612283 Swissprot Accession: P04070;