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Description for Protein PRKX

protein kinase, X-linked
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 3)
Summary:
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.11
    KEGG - Orthology:
    K04345
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04062; hsa04114; hsa04210; hsa04270; hsa04310; hsa04340; hsa04540; hsa04720; hsa04740; hsa04742; hsa04910; hsa04912; hsa04914; hsa04916; hsa04962; hsa04970; hsa05020; hsa05110; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PKX1; Protein kinase Pkx1
    Approved Symbol:
    PRKX
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02097 Entrez Gene ID: 5613 OMIM ID: 300083 Swissprot Accession: P51817;