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Description for Protein MAP2K7

mitogen-activated protein kinase kinase 7
25 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.2
    KEGG - Orthology:
    K04431
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04620; hsa04660; hsa04664; hsa04722; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase kinase 7; MAPKK7; JNK activating kinase 2; JNKK2; MKK7; PRKMK7; MAP kinase kinase 7; c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7
    Approved Symbol:
    MAP2K7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 4; Predicted platelet targets: 3
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04309 Entrez Gene ID: 5609 OMIM ID: 603014 Swissprot Accession: O14733;