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Description for Protein MAP2K6

mitogen-activated protein kinase kinase 6
19 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.2
    KEGG - Orthology:
    K04433
    KEGG - Pathway(s):
    hsa04010; hsa04620; hsa04664; hsa04912; hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase kinase 6; MEK6; MKK6; MAPKK6; MAPK/ERK kinase 6; SAPKK3; Protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); EC 2.7.1.-; PRKMK6
    Approved Symbol:
    MAP2K6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 8
    Human phosphorylation targets: 6; Predicted platelet targets: 3
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03155 Entrez Gene ID: 5608 OMIM ID: 601254 Swissprot Accession: P52564; A8K3Y2;