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Description for Protein MAP2K5

mitogen-activated protein kinase kinase 5
13 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Tyr_Kinase: tyrosine kinase domain
  • PB1: PB1 domain
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.2
    KEGG - Orthology:
    K04463
    KEGG - Pathway(s):
    hsa04010; hsa04540; hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MEK5 alpha; Mitogen activated protein kinase kinase 5; MEK5; MAPK/ERK kinase 5; MAPKK5; PRKMK5; HsT17454; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase MEK5b; Mitogen-activated protein kinase kinase 5 isoform B; Mitogen-activated protein kinase kinase 5 isoform A
    Approved Symbol:
    MAP2K5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03951 Entrez Gene ID: 5607 OMIM ID: 602520 Swissprot Accession: Q13163;