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Description for Protein MAP2K3

mitogen-activated protein kinase kinase 3
17 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.2
    KEGG - Orthology:
    K04432
    KEGG - Pathway(s):
    hsa04010; hsa04620; hsa04664; hsa04912; hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MAPK/ERK kinase 3; MAPKK3; Mitogen activated protein kinase kinase 3; MEK3; Protein kinase, mitogen activated, kinase 3; PRKMK3; MKK3; MAP kinase kinase 3; Dual specificity mitogen activated protein kinase kinase 3; EC 2.7.1.; Mitogen-activated protein kinase kinase 3 isoform A; Mitogen-activated protein kinase kinase 3 isoform B; Mitogen-activated protein kinase kinase 3 isoform C
    Approved Symbol:
    MAP2K3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 5
    Human phosphorylation targets: 3; Predicted platelet targets: 3
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03816 Entrez Gene ID: 5606 OMIM ID: 602315 Swissprot Accession: P46734; Q6FI23;