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Description for Protein MAPK13

mitogen-activated protein kinase 13
10 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 5; undefined: 1)
Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.24
    KEGG - Orthology:
    K04441
    KEGG - Pathway(s):
    hsa04010; hsa04370; hsa04620; hsa04621; hsa04622; hsa04660; hsa04664; hsa04670; hsa04722; hsa04912; hsa04914; hsa05014; hsa05120; hsa05131; hsa05140; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MAP kinase p38 delta; p38d; Mitogen activated protein kinase 13; Stress activated protein kinase 4; SAPK4; PRKM13; p38-delta; Mitogen-activated protein kinase p38 delta
    Approved Symbol:
    MAPK13
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 63
    Human phosphorylation targets: 4; Predicted platelet targets: 59
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09113 Entrez Gene ID: 5603 OMIM ID: 602899 Swissprot Accession: O15264;