Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
S_T_kinase: Serine/Threonine protein kinases, catalytic domain
S_T_Y_Kinase: Protein kinase
unclassified specificity
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Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K04440
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Nomenclature / Alternative Names:
C-JUN kinase 3; MAP kinase 10; SAPKbeta; JNK3; JNK3A; PRKM10; p493F12; FLJ12099; p54bSAPK; MGC50974; MAP kinase; c-Jun kinase 3; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; Stress activated protein kinase JNK3; Stress activated protein kinase beta; EC 2.7.1.37; MAP kinase p49 3F12; Mitogen-activated protein kinase 10 isoform 1; Mitogen-activated protein kinase 10 isoform 3; Mitogen-activated protein kinase 10 isoform 2; Mitogen-activated protein kinase 10 isoform 4
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime(db);
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime(db);
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime(db);
1-(3-BROMOPHENYL)-7-CHLORO-6-METHOXY-3,4-DIHYDROISOQUINOLINE(db);
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One(db);
2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide(db);
4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide(db);
5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide(db);
9-(4-Hydroxyphenyl)-2,7-Phenanthroline(db);
Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine(db);
Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine(db);
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide(db);
N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide(db);
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE(db);
N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine(db);
N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE(db);
Phosphoaminophosphonic Acid-Adenylate Ester(db)
Associated Genetic Diseases:
Epileptic encephalopathy, Lennox-Gastaut type(Pd)
| Predicted Transmembrane Domains:
Isoform 4 : 0
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
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