Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein MAPK9

mitogen-activated protein kinase 9
50 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 7)
Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.24
    KEGG - Orthology:
    K04440
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04310; hsa04510; hsa04620; hsa04621; hsa04622; hsa04660; hsa04664; hsa04722; hsa04910; hsa04912; hsa04914; hsa04920; hsa04930; hsa05120; hsa05131; hsa05142; hsa05200; hsa05210; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PRKM9; C-JUN kinase 2; SAPK1a; JNK2; JNK2A; JNK2B; JNK-55; JNK2beta; p54aSAPK; JNK2alpha; Mitogen-activated protein kinase 9 isoform 2; Mitogen-activated protein kinase 9 isoform 3; Mitogen-activated protein kinase 9 isoform 4; Jun kinase; MAP kinase 9; c-Jun N-terminal kinase 2; Stress-activated protein kinase JNK2; EC 2.7.1.37; Mitogen-activated protein kinase 9 isoform 1
    Approved Symbol:
    MAPK9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 61
    Human phosphorylation targets: 28; Predicted platelet targets: 33
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04206 Entrez Gene ID: 5601 OMIM ID: 602896 Swissprot Accession: P45984; B5M0B4;