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Description for Protein MAPK11

mitogen-activated protein kinase 11
16 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.24
    KEGG - Orthology:
    K04441
    KEGG - Pathway(s):
    hsa04010; hsa04370; hsa04620; hsa04621; hsa04622; hsa04660; hsa04664; hsa04670; hsa04722; hsa04912; hsa04914; hsa05014; hsa05120; hsa05131; hsa05140; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase 11; Protein kinase, mitogen-activated, 11; PRKM11; Stress activated protein kinase 2B; SAPK2B; p38 beta; p38 2; MAP kinase 11; p38 beta 2; P38B; SAPK2; Stress-activated protein kinase-2; EC 2.7.1.37
    Approved Symbol:
    MAPK11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 70
    Human phosphorylation targets: 10; Predicted platelet targets: 60
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04208 Entrez Gene ID: 5600 OMIM ID: 602898 Swissprot Accession: Q15759;