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Description for Protein MAPK8

mitogen-activated protein kinase 8
96 total interacting proteins; 37 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 8; undefined: 1)
Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.24
    KEGG - Orthology:
    K04440
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04310; hsa04510; hsa04620; hsa04621; hsa04622; hsa04664; hsa04722; hsa04910; hsa04912; hsa04914; hsa04920; hsa04930; hsa05120; hsa05131; hsa05142; hsa05200; hsa05210; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    c-Jun kinase 1; c-Jun N-terminal kinase 1; JNK1 alpha protein kinase; Protein kinase JNK1; JNK1 beta protein kinase; PRKM8; SAPK1; JNK21B1/2; JNK1A2; Stress activated protein kinase; JNK; JNK1; EC 2.7.1.37; JNK-46; Mitogen-activated protein kinase 8 isoform 4; Mitogen-activated protein kinase 8 isoform 2; Mitogen-activated protein kinase 8 isoform 3; Mitogen-activated protein kinase 8 isoform 1
    Approved Symbol:
    MAPK8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 139
    Human phosphorylation targets: 49; Predicted platelet targets: 91
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One(db);
  • 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE(db);
  • 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide(db);
  • 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE(db);
  • 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE(db);
  • N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03100 Entrez Gene ID: 5599 OMIM ID: 601158 Swissprot Accession: P45983; A1L4K2;