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Description for Protein MAPK7

mitogen-activated protein kinase 7
16 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • CC: Coiled Coil
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.24
    KEGG - Orthology:
    K04464
    KEGG - Pathway(s):
    hsa04010; hsa04540; hsa04722; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase 7; Extracellular signal regulated kinase 5; BMK1; BMK1 kinase; ERK4; EC 2.7.1.37; PRKM7; ERK5; Mitogen-activated protein kinase 7 isoform 1; Mitogen-activated protein kinase 7 isoform 2
    Approved Symbol:
    MAPK7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 12
    Human phosphorylation targets: 11; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03952 Entrez Gene ID: 5598 OMIM ID: 602521 Swissprot Accession: Q13164;