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Description for Protein NSFL1C

NSFL1 (p97) cofactor (p47)
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/2)
(phosphoproteome: 1; platelet: 2; secretome: 1; undefined: 1)
Summary:
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBA: Ubiquitin associated domain
  • NLS: Nuclear localization signal
  • UBX: Domain present in ubiquitin-regulatory proteins
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    p47; NSFL1 cofactor p47; p97 cofactor p47; p47 protein; NSFL1 (p97) cofactor (p47); p47 protein isoform b; p47 protein isoform c; p47 protein isoform a
    Approved Symbol:
    NSFL1C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 24
    Human (de-) phosphorylation sites: 24; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09425 Entrez Gene ID: 55968 OMIM ID: 606610 Swissprot Accession: Q9UNZ2; A2A2L1; Q53FE8;