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Description for Protein MAPK3

mitogen-activated protein kinase 3
130 total interacting proteins; 61 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 6)
Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.24
    KEGG - Orthology:
    K04371
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04114; hsa04150; hsa04270; hsa04320; hsa04350; hsa04360; hsa04370; hsa04510; hsa04520; hsa04540; hsa04620; hsa04621; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04720; hsa04722; hsa04730; hsa04810; hsa04910; hsa04912; hsa04914; hsa04916; hsa04930; hsa04960; hsa05010; hsa05020; hsa05131; hsa05140; hsa05142; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase 3; PRKM3; Extracellular signal regulated kinase 1; Protein kinase, mitogen activated, 3; p44ERK1; p44MAPK; EC 2.7.1.37; Insulin stimulated MAP2 kinase; Microtubule associated protein 2 kinase; Mitogen-activated protein kinase 3 isoform 1; Mitogen-activated protein kinase 3 isoform 2
    Approved Symbol:
    MAPK3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 124
    Human phosphorylation targets: 123; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-iodotubercidin(db);
  • Arsenic trioxide(db);
  • Purvalanol(db);
  • Sulindac(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03479 Entrez Gene ID: 5595 OMIM ID: 601795 Swissprot Accession: P27361; Q9BWJ1; A8CZ58;