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Description for Protein ERBB2IP

erbb2 interacting protein
28 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/2)
(membrane: 1; phosphoproteome: 1; platelet: 11; undefined: 1)
Summary:
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LRR: Leucine-rich repeats, outliers
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12796
    KEGG - Pathway(s):
    hsa04621
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Erbb2 interacting protein; Densin 180 like protein; LAP2 protein; KIAA1225; ERBB2 interacting protein isoform 7; ERBB2 interacting protein isoform 2
    Approved Symbol:
    ERBB2IP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 52
    Human (de-) phosphorylation sites: 52; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06090 Entrez Gene ID: 55914 OMIM ID: 606944 Swissprot Accession: Q96RT1;