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Description for Protein PRKDC

protein kinase, DNA-activated, catalytic polypeptide
81 total interacting proteins; 35 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family. (PubMed Links)
Domains and Motifs:
  • LZ: Leucine Zipper
  • PI3KC: Phosphoinositide 3-kinase, catalytic domain
  • HEAT: HEAT repeat
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K06642
    KEGG - Pathway(s):
    hsa03450; hsa04110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein kinase DNA activated, catalytic subunit; DNA dependent protein kinase, catalytic subunit; p350; DNA PKcs; DNPK1; DNAPK; Protein kinase, DNA-activated, catalytic polypeptide isoform 2; EC 2.7.11.1; DNA-PK catalytic subunit; p460; HYRC; HYRC1; XRCC7; Hyperradiosensitivity complementing 1
    Approved Symbol:
    PRKDC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 46
    Human (de-) phosphorylation sites: 46; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 49
    Human phosphorylation targets: 30; Predicted platelet targets: 19
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02941 Entrez Gene ID: 5591 OMIM ID: 600899 Swissprot Accession: P78527;