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Description for Protein ACSS2

acyl-CoA synthetase short-chain family member 2
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.2.1.1
KEGG - Orthology:
K01895
KEGG - Pathway(s):
hsa00010; hsa00620; hsa00640; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Acetyl-CoA synthetase; ACS; ACSA; AceCS; Acetate thiokinase; Acetate-CoA ligase; Acyl-activating enzyme; Cytoplasmic acetyl-coenzyme A synthetase; Acetyl-Coenzyme A synthetase 2 (ADP forming); dJ1161H23.1; MYH7B; DKFZp762G026; Acyl-CoA synthetase short-chain family member 2; OTTHUMP00000030712; OTTHUMP00000030714; OTTHUMP00000030715; OTTHUMP00000030716; EC 6.2.1.13; EC 6.2.1.1; Acetyl-coenzyme A synthetase, cytoplasmic; ACAS2; Acyl-CoA synthetase short-chain family member 2 isoform a; Acyl-CoA synthetase short-chain family member 2 isoform 2
Approved Symbol:
ACSS2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; Platelet phosphorylation sites: 1
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine monophosphate(db);
  • Adenosine triphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12053 Entrez Gene ID: 55902 OMIM ID: 605832 Swissprot Accession: Q9NR19; Q8N238; Q6DKJ3;