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Description for Protein PRKCZ

protein kinase C, zeta
83 total interacting proteins; 51 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • PB1: PB1 domain
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.13
    KEGG - Orthology:
    K06069
    KEGG - Pathway(s):
    hsa04062; hsa04144; hsa04530; hsa04910; hsa04930
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PKC Zeta; PKCZ; PKC2; OTTHUMP00000044160; EC 2.7.1.37; Protein kinase C, zeta isoform 1; Protein kinase C, zeta isoform 2
    Approved Symbol:
    PRKCZ
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 54
    Human phosphorylation targets: 34; Predicted platelet targets: 20
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01504 Entrez Gene ID: 5590 OMIM ID: 176982 Swissprot Accession: Q05513; A8MU64;