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Description for Protein PRKCSH

protein kinase C substrate 80K-H
8 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(microparticles: 1; platelet: 1; secretome: 2; undefined: 1)
Summary:
This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER). This protein is an acidic phospho-protein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease (PCLD). Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
  • LDLA: Low-density lipoprotein receptor domain class A
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08288
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Protein kinase C substrate 80K-H; PCLD; G19P1; AGE-R2; Hepatocystin; 80K-H protein; AGE binding receptor 2; Protein kinase C substrate 80 Kda protein; Protein kinase C substrate 80K-H isoform 1; Protein kinase C substrate 80K-H isoform 2; Protein kinase C substrate 80-KD heavy chain; Protein kinase C substrate 60.1 kDa protein heavy chain
    Approved Symbol:
    PRKCSH
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Polycystic liver disease(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03518 Entrez Gene ID: 5589 OMIM ID: 177060 Swissprot Accession: P14314; A8K318;