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Description for Protein ASH1L

ash1 (absent, small, or homeotic)-like (Drosophila)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AT_hook: DNA binding domain with preference for A/T rich regions
  • SET: SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  • BROMO: bromo domain
  • PHD: PHD zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.43
    KEGG - Orthology:
    K06101
    KEGG - Pathway(s):
    hsa00310; hsa04530
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ash1; Achaete scute homologue 1; KIAA1420
    Approved Symbol:
    ASH1L
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06416 Entrez Gene ID: 55870 OMIM ID: 607999 Swissprot Accession: Q9NR48;