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Description for Protein PKN1

protein kinase N1
27 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HR1: Rho effector or protein kinase C-related kinase homology region 1 homologues
  • CC: Coiled Coil
  • C2: Protein kinase C conserved region 2 (CalB)
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.13
    KEGG - Orthology:
    K06071
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PKN; PRKCL1; Protein kinase C like 1; Protein kinase C related kinase 1; PRK1; Protein kinase N1 isoform 1; Protein kinase N1 isoform 2
    Approved Symbol:
    PKN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 49
    Human (de-) phosphorylation sites: 49; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 24
    Human phosphorylation targets: 6; Predicted platelet targets: 18
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03019 Entrez Gene ID: 5585 OMIM ID: 601032 Swissprot Accession: Q16512;