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Description for Protein PRKCE

protein kinase C, epsilon
57 total interacting proteins; 42 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • C2: Protein kinase C conserved region 2 (CalB)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.13
    KEGG - Orthology:
    K06068
    KEGG - Pathway(s):
    hsa04270; hsa04530; hsa04664; hsa04666; hsa04930
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PKC epsilon; PKCE; nPKC epsilon
    Approved Symbol:
    PRKCE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 29
    Human phosphorylation targets: 29; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01500 Entrez Gene ID: 5581 OMIM ID: 176975 Swissprot Accession: Q02156;