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Description for Protein PRKCB

protein kinase C, beta
79 total interacting proteins; 42 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/3)
(membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 5; undefined: 2)
Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • C2: Protein kinase C conserved region 2 (CalB)
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.13
    KEGG - Orthology:
    K02677
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04020; hsa04062; hsa04070; hsa04270; hsa04310; hsa04370; hsa04510; hsa04530; hsa04540; hsa04650; hsa04662; hsa04664; hsa04666; hsa04670; hsa04720; hsa04730; hsa04912; hsa04916; hsa04960; hsa04970; hsa05110; hsa05140; hsa05200; hsa05214; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PKCB; PRKCB; PRKCB2; PKC beta; PKC-B; MGC41878; EC 2.7.1.37; Protein kinase C, beta; Protein kinase C, beta 1 polypeptide; Protein kinase C, beta isoform 2; Protein kinase C, beta isoform 1
    Approved Symbol:
    PRKCB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 53
    Human phosphorylation targets: 53; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • O-Phosphoethanolamine(db);
  • Vitamin E(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01499 Entrez Gene ID: 5579 OMIM ID: 176970 Swissprot Accession: P05771;