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Description for Protein PRKCA

protein kinase C, alpha
185 total interacting proteins; 95 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(ATP binding: 1; membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • C2: Protein kinase C conserved region 2 (CalB)
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.13
    KEGG - Orthology:
    K02677
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04020; hsa04070; hsa04270; hsa04310; hsa04370; hsa04510; hsa04530; hsa04540; hsa04650; hsa04664; hsa04666; hsa04670; hsa04720; hsa04730; hsa04912; hsa04916; hsa04960; hsa04970; hsa05110; hsa05130; hsa05200; hsa05214; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PKC alpha
    Approved Symbol:
    PRKCA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 237
    Human phosphorylation targets: 219; Predicted platelet targets: 21
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphatidylserine(db);
  • Vitamin E(db)

    Associated Genetic Diseases:

  • Pituitary tumor, invasive, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01498 Entrez Gene ID: 5578 OMIM ID: 176960 Swissprot Accession: P17252; B5BU22; Q7Z727;