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Description for Protein PRKAR2A

protein kinase, cAMP-dependent, regulatory, type II, alpha
37 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(cAMP/cGMP binding: 1; phosphoproteome: 1; platelet: 8; undefined: 1)
Summary:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CNMP: Cyclic nucleotide-monophosphate binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04739
    KEGG - Pathway(s):
    hsa04210; hsa04910
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein kinase A, RII alpha subunit
    Approved Symbol:
    PRKAR2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01484 Entrez Gene ID: 5576 OMIM ID: 176910 Swissprot Accession: P13861; Q9BUB1;