Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
32 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; platelet: 7; secretome: 1; undefined: 1)
Summary:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CNMP: Cyclic nucleotide-monophosphate binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04739
    KEGG - Pathway(s):
    hsa04210; hsa04910
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PRKAR1; Tissue specific extinguisher 1; TSE1; PTC2 chimeric oncogene; cAMP dependent protein kinase type I-alpha regulatory chain; Protein kinase, cAMP-dependent, regulatory, type I, alpha; CAR; CNC1; MGC17251; DKFZp779L0468; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase, regulatory subunit alpha 1; PKR1; Protein kinase A R1 alpha regulatory subunit
    Approved Symbol:
    PRKAR1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cyclic Adenosine Monophosphate(db);
  • Cyclic Guanosine Monophosphate(db);
  • Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate(db)

    Associated Genetic Diseases:

  • Adrenocortical tumor, somatic(Pd);
  • Carney complex, type 1(Pd);
  • Myxoma, intracardiac(Pd);
  • Primary pigmented nodular adrenocortical disease 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01786 Entrez Gene ID: 5573 OMIM ID: 188830 Swissprot Accession: P10644; B2R5T5;