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Description for Protein PRKAG1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit
15 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CBS: Domain in cystathionine beta-synthase and other proteins.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07200
    KEGG - Pathway(s):
    hsa04910; hsa04920; hsa05410
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AMPKg; Protein kinase, AMP-activated, gamma 1 non-catalytic subunit; MGC8666; AMP-activated protein kinase, noncatalytic gamma-1 subunit; AMPK gamma-1 chain; 5 prime AMP-activated protein kinase, gamma-1 subunit; AMP-activated protein kinase, noncatalytic gamma-1 subunit isoform 1; AMP-activated protein kinase, noncatalytic gamma-1 subunit isoform 2
    Approved Symbol:
    PRKAG1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04118 Entrez Gene ID: 5571 OMIM ID: 602742 Swissprot Accession: P54619;