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Description for Protein PRKACB

protein kinase, cAMP-dependent, catalytic, beta
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(membrane: 1; microparticles: 1; platelet: 16; secretome: 7)
Summary:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Three alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.11
    KEGG - Orthology:
    K04345
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04062; hsa04114; hsa04210; hsa04270; hsa04310; hsa04340; hsa04540; hsa04720; hsa04740; hsa04742; hsa04910; hsa04912; hsa04914; hsa04916; hsa04962; hsa04970; hsa05020; hsa05110; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EC 2.7.1.37; MGC9320; MGC41879; DKFZp781I2452; cAMP-dependent protein kinase catalytic subunit beta isoform 1; cAMP-dependent protein kinase catalytic subunit beta isoform 2; cAMP-dependent protein kinase catalytic subunit beta isoform 3; PKA C beta; cAMP dependent protein kinase, beta catalytic subunit
    Approved Symbol:
    PRKACB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 37
    Human phosphorylation targets: 1; Predicted platelet targets: 36
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphonothreonine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01482 Entrez Gene ID: 5567 OMIM ID: 176892 Swissprot Accession: P22694; B2RB89;