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Description for Protein PRKAB1

protein kinase, AMP-activated, beta 1 non-catalytic subunit
22 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K07199
KEGG - Pathway(s):
hsa04910; hsa04920; hsa05410
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
AMP activated protein kinase beta subunit; AMPKb; AMPK; AMP-activated protein kinase beta 1 non-catalytic subunit; HAMPKb; 5`-AMP-activated protein kinase beta-1 subunit; AMPK beta-1 chain
Approved Symbol:
PRKAB1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 20
Human (de-) phosphorylation sites: 20; Platelet phosphorylation sites: 4
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine monophosphate(db);
  • Metformin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04116 Entrez Gene ID: 5564 OMIM ID: 602740 Swissprot Accession: Q9Y478;