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Description for Protein SMPD4

sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 [PubMed 16517606]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.12
    KEGG - Orthology:
    K12353
    KEGG - Pathway(s):
    hsa00600; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LOC55627; Hypothetical protein LOC55627 isoform 1; Hypothetical protein LOC55627 isoform 2; NSMASE3; FLJ20297; EC 3.1.4.12; KIAA1418; Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3); Neutral sphingomyelinase 3; Neutral sphingomyelinase III; nSMase3
    Approved Symbol:
    SMPD4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphatidylserine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 13374 Entrez Gene ID: 55627 OMIM ID: 610457 Swissprot Accession: B4DM23; B1PBA3; Q9NXE4;