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Description for Protein PRKAA1

protein kinase, AMP-activated, alpha 1 catalytic subunit
34 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.11
    KEGG - Orthology:
    K07198
    KEGG - Pathway(s):
    hsa04140; hsa04150; hsa04910; hsa04920; hsa05410
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AMPK1; Protein kinase, AMP-activated, alpha 1 catalytic subunit; AMPKa1; MGC33776; MGC57364; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; 5` -AMP-activated protein kinase, catalytic alpha-1 chain; Protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2; Protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 1
    Approved Symbol:
    PRKAA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 61
    Human (de-) phosphorylation sites: 61; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 43
    Human phosphorylation targets: 30; Predicted platelet targets: 15
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine monophosphate(db);
  • Adenosine triphosphate(db);
  • Phenformin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04115 Entrez Gene ID: 5562 OMIM ID: 602739 Swissprot Accession: Q13131;