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Description for Protein ASAP3

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • ARFGAP: Putative GTP-ase activating proteins for the small GTPase, ARF
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12488
    KEGG - Pathway(s):
    hsa04144; hsa04666
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Up regulated in liver cancer 1; FLJ20199; ACAP4; UPLC1; CENTB6; Centaurin, beta 6; Protein up-regulated in liver cancer 1
    Approved Symbol:
    ASAP3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11662 Entrez Gene ID: 55616 OMIM ID: - Swissprot Accession: Q8TDY4; B4DHH4;