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Description for Protein OTUB1

OTU domain, ubiquitin aldehyde binding 1
22 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(platelet: 4; secretome: 1)
Summary:
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.4.-.-
KEGG - Orthology:
K09602
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
OTU domain containing ubal binding protein 1; OTU domain containing ubiquitin aldehyde binding protein; Ubiquitin specific protease otubain 1; FLJ20113; Deubiquitinating enzyme OTUB1; HSPC263; Ubiquitin thiolesterase protein OTUB1; OTU1; OTB1
Approved Symbol:
OTUB1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08493 Entrez Gene ID: 55611 OMIM ID: 608337 Swissprot Accession: B3KUV5; Q96FW1;