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Description for Protein SOX6

SRY (sex determining region Y)-box 6
8 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • HMG: high mobility group
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09269
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SRY box 6; Transcription factor SOX6; SRY-box containing gene 6; SRY (sex determining region Y)-box 6; HSSOX6; SRY (sex determining region Y)-box 6 isoform 1; SRY (sex determining region Y)-box 6 isoform 2
    Approved Symbol:
    SOX6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06267 Entrez Gene ID: 55553 OMIM ID: 607257 Swissprot Accession: P35712;