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Description for Protein PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
11 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10786
    KEGG - Pathway(s):
    hsa05310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Bone-marrow proteoglycan; Natural killer cell activator; Eosinophil major basic protein; Eosinophil granule major basic proteinB; MBP; BMPG; MGC14537; Pregnancy associated major basic protein; Proteoglycan 2 bone marrow
    Approved Symbol:
    PRG2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sargramostim(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09283 Entrez Gene ID: 5553 OMIM ID: 605601 Swissprot Accession: P13727;