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Description for Protein PREP

prolyl endopeptidase
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(microparticles: 1; platelet: 3; secretome: 2)
Summary:
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.4.21.26
KEGG - Orthology:
K01322
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Prolyl oligopeptidase; Proline endopeptidase; Post proline cleaving enzyme; PE; TRH deamidase; Endooligopeptidase B
Approved Symbol:
PREP
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one(db);
  • 1-Hydroxy-1-Thio-Glycerol(db);
  • 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one(db);
  • 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione(db);
  • Double Oxidized Cysteine(db);
  • Monothioglycerol(db);
  • Oxytocin(db);
  • S-Oxy Cysteine(db);
  • Z-Pro-Prolinal(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02673 Entrez Gene ID: 5550 OMIM ID: 600400 Swissprot Accession: P48147; Q9UM02;