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Description for Protein PARL

presenilin associated, rhomboid-like
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.105
    KEGG - Orthology:
    K09650
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PARL; PRO2207; PSENIP2; PSARL1; Presenilin associated, rhomboid-like isoform 2 preproprotein; RHBDS1; Rhomboid 7 homolog 1; Mitochondrial intramembrane-cleaving protease PARL; EC 3.4.21.105; PSARL
    Approved Symbol:
    PARL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 08484 Entrez Gene ID: 55486 OMIM ID: 607858 Swissprot Accession: Q9H300;