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Description for Protein PRCP

prolylcarboxypeptidase (angiotensinase C)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.16.2
    KEGG - Orthology:
    K01285
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PCP; Proline carboxypeptidase; Angiotensinase C; Lysosomal carboxypeptidase C; HUMPCP; MGC2202; Lysosomal Pro x carboxypeptidase; EC 3.4.16.2; Prolylcarboxypeptidase isoform 1 preproprotein; Prolylcarboxypeptidase isoform 2
    Approved Symbol:
    PRCP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 08352 Entrez Gene ID: 5547 OMIM ID: 176785 Swissprot Accession: P42785; A8MU24; B3KRK5;