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Description for Protein PRCC

papillary renal cell carcinoma (translocation-associated)
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle. (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13105
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Papillary renal cell carcinoma translocation associated gene protein; RCCP1; Proline rich protein PRCC; MGC4723; MGC17178; Papillary renal cell carcinoma translocation-associated gene product isoform 2; Papillary renal cell carcinoma translocation-associated gene product isoform 1
    Approved Symbol:
    PRCC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01562 Entrez Gene ID: 5546 OMIM ID: 179755 Swissprot Accession: Q92733; A6NG79; Q96FT4;