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Description for Protein LRDD

leucine-rich repeats and death domain containing
9 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LRR: Leucine-rich repeats, outliers
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
  • ZU5: Domain present in ZO-1 and Unc5-like netrin receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10130
    KEGG - Pathway(s):
    hsa04115
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Leucine rich repeat and death domain containing protein isoform 3; Leucine rich repeat and death domain containing protein isoform 2; Leucine rich repeat and death domain containing protein; MGC16925; Leucine rich repeat and death domain containing protein isoform 1
    Approved Symbol:
    LRDD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11284 Entrez Gene ID: 55367 OMIM ID: 605247 Swissprot Accession: Q9HB75;