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Description for Protein PPP3CC

protein phosphatase 3, catalytic subunit, gamma isozyme
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PP2A: Protein phosphatase 2A homologues, catalytic domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K04348
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04114; hsa04210; hsa04310; hsa04360; hsa04370; hsa04650; hsa04660; hsa04662; hsa04720; hsa05010; hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein phosphatase 3, catalytic subunit, gamma isoform CALNA3; Calcineurin A-gamma Protein phosphatase 2B, catalytic subunit, gamma isoform
    Approved Symbol:
    PPP3CC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00236 Entrez Gene ID: 5533 OMIM ID: 114107 Swissprot Accession: P48454;