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Description for Protein PI4K2B

phosphatidylinositol 4-kinase type 2 beta
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PI3KC: Phosphoinositide 3-kinase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.67
    KEGG - Orthology:
    K13711
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FLJ11105; PI4KIIB; PIK42B; 2610042N09Rik; 4933409G22Rik
    Approved Symbol:
    PI4K2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15132 Entrez Gene ID: 55300 OMIM ID: 612101 Swissprot Accession: Q8TCG2;